The influenza virus vaccination is clinically safe for patients with systemic lupus, even though it may trigger the generation of autoantibodies in some patients.
Mahmoud Abu-Shakra, MD, at the Soroka Medical Center, in Beer-Sheva, Israel, and colleagues investigated the effects of the influenza vaccine on 24 women with systemic lupus erythematosus.
Blood samples from each woman were withdrawn at the time of vaccination and at six and 12 weeks after vaccination. The sera were then tested by enzyme-linked immunoabsorbent assay (ELISA) for anti-DNA, anticardiolipin, anti-Sm, anti-Sm/RNP, anti-Ro and anti-La antibodies.
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