People whose asthma is not well-controlled with budesonide alone might do well to add oral montelukast to their inhaled steroid rather than doubling the dose of budesonide. The improvements in lung function are more or less the same with either regimen, but the montelukast/budesonide combination might offer a benefit in terms of convenience with better efficacy as well.
In a presentation at the 12th annual meeting of the European Respiratory Society held here this week, investigators released a sub-analysis from the COMPACT (Clinical Observation of Montelukast as a Partner Agent for Complementary Therapy) study.
This part of the COMPACT study involved 889 adults in 11 countries whose asthma was not well controlled by 400 mcg bid budesonide alone and who had an FEV1 of 50 percent or more of the predicted. As part of the run-in period, patients were allowed to use 400 mcg bid of budesonide (i.e. 800mcg/day) as well as a beta agonist as rescue medication, if needed.
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