Short-term folic acid supplementation appears to enhance endothelial function and reduce blood pressure in healthy chronic smokers, indicates a study presented here at the 24th Congress of the European Society of Cardiology.
Cigarette smoking is associated with plasma homocysteine, endothelial dysfunction and arterial stiffening. Therefore, Dr. Arduino Aleksander Mangoni, of the Department of Health Care of the Elderly, Kings College, in London, England, and colleagues aimed to test the hypothesis that folic acid would lower smokers’ concentrations of homocysteine and thus improve some of the abnormalities induced by homocysteine.
The double-blind study enrolled 24 healthy chronic cigarette smokers with no history of cardiovascular disease, hypertension, diabetes or other conditions affecting the cardiovascular system, who were randomised to four weeks of folic acid 5 mg/day or placebo. Blood pressure, carotid-femoral pulse-wave velocity and peripheral vasoreactivity were measured before and after treatment.
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