There is an urgent need for a prospective, scientific assessment of the process involved for selection of donors for lung transplantation in the United States, researchers say.
Their assessment of 29 pairs of rejected lungs found that almost half of would have been potentially suitable for transplantation. Current selection criteria rule out more than 85 percent of donor lungs despite reported success with lungs from marginal donors. Very few studies have looked at the condition of rejected lungs, the clinicians note.
Dr. Lorraine Ware and colleagues from Vanderbilt University School of Medicine, in Nashville, Tennessee, and Dr. Michael Matthay and colleagues from University of California at San Francisco, used physiological, microbiological, and histological methods to determine whether lungs that were being rejected using current criteria were potentially suitable.
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