05/21/2002 By Elda Hauschildt
Analysis of exhaled breath condensate may be useful in studying allergic inflammation in patients with childhood asthma.
Researchers from the National Heart and Lung Institute and Royal Brompton Hospital in London, England, have shown that interferon-g (IFN-g) and interleukin-4 (IL-4) can be assayed in exhaled breath condensate of children.
They report assays completed on exhaled breath condensate in 37 children show an increased ratio of IL-4:IFN-g in the airways of children with asthma consistent with a predominance of T-helper-2 cells. IL-4 and IFN-g concentrations were measured in 11 healthy children, 12 steroid-naïve asthmatic children and 14 steroid-treated asthmatics.
The investigators observed exhaled IFN-g was significantly lower in the steroid-naïve and steroid-treated asthmatic children compared with control children. Mean exhaled IL-4 was elevated in the asthmatic patients compared with healthy controls.
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