מתוך medicontext.co.il
WESTPORT, CT (Reuters Health) – In patients with pulmonary hypertension, 100% supplemental oxygen is a selective pulmonary vasodilator that improves pulmonary vascular resistance and cardiac index, researchers report.
Dr. Leo C. Ginns from Massachusetts General Hospital in Boston and colleagues studied 23 patients with pulmonary hypertension without left-heart failure. The patients underwent cardiac catheterization while breathing air and then 100% oxygen, the research team reports in the November issue of Chest.
Oxygen therapy increased arterial oxygen saturation from a mean of 91% to 99% (p < 0.05) and PaO2 from a mean of 64 mm Hg to 309 mm Hg (p < 0.05), the researchers found.
With oxygen therapy mean pulmonary artery pressure was reduced from 56 mg Hg to 53 mm Hg (p < 0.05) and mean cardiac index increased from 2.1 L/min/m² to 2.5 L/min/m² (p < 0.05). Also, mean pulmonary vascular resistance fell from 14.1 Wood units to 10.6 Wood units (p < 0.05), Dr. Ginns and his associates note.
They conclude that "further studies are indicated to document whether a dose-response relationship exists for oxygen therapy, whether the short-term beneficial effects of oxygen are maintained over the course of long-term therapy, and perhaps to help define more appropriate disease-specific guidelines for the prescription of supplemental oxygen therapy."
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