WESTPORT, CT (Reuters Health) – The inactivated influenza vaccine may be administered safely to adults and children with asthma, even those with severe asthma, according to a report in the November 22nd issue of The New England Journal of Medicine.
Dr. Mario Castro from Washington University School of Medicine in St. Louis, Missouri and colleagues from the American Lung Association Asthma Clinical Research Centers investigated the safety of the inactivated trivalent split-virus influenza vaccine in 2032 asthma patients ranging in age from 3 to 64 years.
Asthma exacerbations during the 14 days after injection were equivalent among patients who received the vaccine (28.8%) and those who received placebo (27.7%), the authors report. The two groups of patients also experienced similar daily mean peak expiratory flow rates and bronchodilator rescue medication use.
In fact, the researchers note, none of the other asthma-related outcomes differed between the vaccine injection and placebo injection groups, either overall or for any of the asthma severity subgroups.
"We have no reason to believe that there should be any difference with other strains used in the inactivated influenza vaccine," Dr. Castro told Reuters Health.
"All asthmatics, regardless of age [or] severity, should receive the influenza vaccine on a yearly basis," he said. "All physicians who can provide vaccines should have reminder mechanisms in place in their practice to increase vaccination rates, especially in their asthmatics."
"The American Lung Association sponsored this research and needs to be recognized," Dr. Castro added. "Remember Christmas Seals donations."
N Engl J Med 2001;345:1529-1536.
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