מתוך medicontext.co.il
WESTPORT, CT (Reuters Health) – Eosinophilic airway inflammation is among factors associated with persistent airflow limitation in severe asthmatics, according to Dutch researchers.
Dr. Anneke ten Brinke and colleagues at Leiden University Medical Center note that "the risk factors for airways obstruction with incomplete reversibility in asthma are unknown."
To investigate, the researchers studied 132 patients with severe asthma. All were nonsmokers and had made regular use of inhaled corticosteroids and/or daily use of oral corticosteroids and long-acting bronchodilators for more than 1 year.
The patients underwent a variety of tests including spirometry, histamine challenge, exhaled nitric oxide evaluation and sputum induction and processing.
Analysis of the results showed that 49% of patients had persistent airflow limitation, the team reports in the September 1st issue of the American Journal of Respiratory and Critical Care Medicine.
"Apart from older age and longer asthma duration," persistent airflow limitation was most strongly associated with sputum eosinophils of 2% or more (odds ratio, 7.7), bronchial hyperreactivity to challenge with 1 mg/mL or less of histamine (odds ratio, 3.9) and onset of asthma in adulthood (odds ratio, 3.3). However, sputum eosinophilia, with an adjusted odds ratio of 8.9, was the only independent factor.
The investigators conclude that persistent airflow limitation is a frequent finding in such patients, but "whether reduction of sputum eosinophils with more vigorous treatment leads to a better prognosis in severe asthma is still an open question."
e-Med Tools
קצר קולע וממוקד
e-Med סמינרים
אי-מד תחקירים
Medscape Tools
Journal Club
מרכזי מידע ושירות
Facebook
מידע למפרסם
מאגר תרופות
מאגר אנשי המקצוע
אינדקס שימושי
חדשות משה"ב
eMed HealthClub
מחקרים קליניים
השאירו תגובה
רוצה להצטרף לדיון?תרגישו חופשי לתרום!