Children with tuberous sclerosis complex who suffer from drug-resistant epileptic seizures may benefit from epilepsy surgery, provided a leading epileptogenic tuber can be identified through imaging studies. M. Karenfort and colleagues from the Epilepsy-Center Bethel, Klinik Mara I, Bielefeld, Germany, examined nine children with tuberous sclerosis complex suffering from severe, drug-resistant seizures.
Their goal was to identify a leading epileptogenic tuber. All the children underwent long-term video electroencephalogram (EEG) monitoring as well as several neuroimaging studies and neuropsychological tests. Using the above techniques, the investigators were able to identify a leading epileptogenic tuber in all nine patients. Eight patients underwent epilepsy surgery and all of them had fewer seizures postoperatively.
Two of the patients became seizure-free, one had a single, prolonged seizure five days after the surgery, four patients had a more than 75 percent reduction in seizures and one had a more than 50 percent reduction in seizures. Patients did not experience additional neurologic deficits following surgery.
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