Although borderline personality disorder is poorly treated with existing pharmacotherapy, results of a double-blind, placebo-controlled pilot study reported in the January issue of the American Journal of Psychiatry suggest that women with this condition may be partially reponsive to ethyl-eicosapentaenoic acid (E-EPA).
“Because response to antidepressants and mood stabilizers has typically been clinically modest in [borderline personality disorder] the identification of novel treatments is needed,” write Mary C. Zanarini, EdD, and Frances R. Frankenburg, MD, from McLean Hospital in Belmont, Massachusetts. “Candidates include omega-3 fatty acids, such as E-EPA and docosahexaenoic acid, which are commonly found in seafood and have beneficial effects and none of the adverse side effects commonly associated with pharmacotherapy.”
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