Use of propofol to sedate epileptic children prior to undergoing positron emission tomography (PET) scanning may result in bilateral parieto-occipital hypometabolism. Researchers, led by F. D. Juengling, department of radiology, division of nuclear medicine, University Hospital Freiburg, Germany, explored whether sedating children with propofol prior to cerebral PET scanning interferes with the results of the scan.
Twenty-four children with severe myoclonic epilepsy were sedated with propofol prior to undergoing PET scanning. The results of their scans were compared with those of a healthy adult control group and an age-matched child intra-group control.
PET scans revealed statistically significant hypometabolic areas in the medial parieto-occipital cortex bilaterally, including the lingual gyrus, cuneus, posterior cingulate and middle occipital gyrus of the sedated children compared with each of the control groups. All of these localizations correlated with the injected dose of propofol that the children were sedated with (P<0.01).
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