Third trimester exposure to paroxetine may cause neonatal complications due most likely to withdrawal syndrome, according to a report in the November issue of the Archives of Pediatric and Adolescent Medicine.
“Paroxetine hydrochloride (Paxil) is commonly used for maternal depression, panic disorder, and obsessive-compulsive disorder in pregnant women,” write Adriana M. Costei, MD, and colleagues from the Hospital for Sick Children in Toronto, Ontario, Canada. “Although the drug does not appear to cause major congenital malformations, its perinatal safety when used in late gestation has not been established.”
In this prospective, controlled cohort study, 55 pregnant women counseled prospectively regarding their third-trimester exposure to paroxetine were compared with 27 women using paroxetine during the first or second trimester and with 27 women using nonteratogenic drugs. The groups were matched for maternal age, gravity, parity, social drug use, and nonteratogenic drug use.
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