Calcium channel blockers appear to offer a more effective and comfortable technique for opiate detoxification when compared with more conventional regimens.
Based on their findings with the use of calcium channel blockers, compared with controls groups receiving nimodipine and dextropropoxiphen, or beta- 2-adrenergic agents and naltrexone, researchers think the findings now warrant a randominised controlled trial.
Dr. Juan Manuel Jiménez-Lerma and colleagues at the Addiction Treatment Center of Alva and other colleagues in the Basque Health Service, Vitoria-Gasteiz, Spain, evaluated the use of L-type calcium channel blockers over seven days at out-patient opiate detoxification clinics.
Thirty patients received a course of nimodipine and dextropropoxiphen. One control group of 20 patients received a course of dextropropoxiphen and benzodiazepine; and a second control group of 30 patients received a standard course of beta-2-adrenergic agents and naltrexone. In all groups, detoxification was scheduled over seven days.
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