The Ca2+-permeable AMPA-type glutamate receptors on the surface of glioblastoma cells facilitate the cells’ migration and proliferation, Japanese investigators report in the advance online publication of Nature Medicine for August 12.
Blocking Ca2+ influx may represent a potential strategy to prevent invasion by this malignant tumor. Dr. Shogo Ishiuchi, of the Gunma University School of Medicine, and associates examined stained sections of surgical glioblastoma specimens and observed abundant expression of Ca2+-permeable subunits of the AMPA receptors. The morphology of these cells, also found in invading undifferentiated tumor cells, was fusiform, often with long cellular processes.
Only a few tumor cells expressed the Ca2+-impermeable subunits of AMPA receptors, whereas normal neurons expressed these subunits abundantly. Cells expressing this subunit were of a polygonal and flattened shape.
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