06/07/2002 By Anne MacLennan
Delusions and depression are strongly associated in Alzheimer’s disease, and management of both of these conditions must be taken into account in patients with Alzheimer’s.
Presence of depression conferred a 1.8-fold higher risk of delusions before researchers accounted for a range of potentially confounding factors in this study of patients with probable Alzheimer’s disease (AD) at Johns Hopkins School of Medicine, Baltimore, Maryland, United States.
The risk increased further to 6.8-fold after these multiple other variables were considered. Delusions in AD are strongly associated with depression even after statistical adjustment for all confounding variables, which might distort this association.
This finding has implications not only for understanding of the etio-pathogenesis of both delusions and depression but also for their management in AD patients, suggest these authors.
Medhat M. Bassiony from Zagazig University, Elsharkia, Egypt did this cross-sectional case-control investigation of the link between delusions and depression in AD patients with others at Johns Hopkins Neuropsychiatry Service and Copper Ridge Institute, Sykesville, Maryland.
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