06/05/2002 By Anne MacLennan
Further study is needed in order to identify optimal toxin preparations for botulinum toxin therapy in neurologic disorders, suggests a study in Germany.
For a limited period of time, however, low-dose treatment of cervical dystonia with Dysport (TM) may be clinically effective during maintenance therapy, researchers from the Movement Disorders Clinic, Department of Neurology, University of Tubingen, Tubingen, have found.
The study authors acknowledge, though, that the long-lasting effects of previous Dysport treatments at conventional doses and possibly improved diffusion of a highly diluted toxin preparation may have contributed to the effects of the low-dose regimen found in this study.
Ulrike Laubis-Herrmann and colleagues evaluated the clinical efficacy of low-dose botulinum
toxin treatment of cervical dystonia in this double-blind, randomised pilot study.
Thirty-one participating cervical dystonia patients, all with a minimum of two previous Dysport treatments, received either a mean total target dose of 547 ± 113 mouse units (MU) (group A, 500 MU Dysport/ml) or a four-times-diluted preparation 130 ± 32 MU (group B, 125 MU Dysport/ml).
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