Markers of oxidative damage are increased in patients with Alzheimer disease (AD) and correlate with decreased levels of plasma antioxidants.
In a study of 40 AD patients, lymphocyte content of 8-hydroxy-2′-deoxyguanosine (8-OHdG), a marker of oxidative damage to DNA, was significantly higher and plasma levels of antioxidants (except for lutein) significantly lower in patients than in healthy controls. Lymphocyte DNA 8-OHdG content in people AD may thus reflect a condition of increased oxidative stress related to a poor antioxidant status, these authors suggest.
Patrizia Mecocci led this three-country project with colleagues from the Institute of Gerontology and Geriatrics, University of Perugia, Perugia, Italy with contributors from the Institute of Physiological Chemistry, Heinrich-Heine University, Dusseldorf, Germany and Weill Medical College of Cornell University and the New York Hospital, Cornell Medical Center, New York.
Although a large body of experimental evidence suggests oxidative stress plays a key role in AD pathogenesis, there have been few data on in vivo markers of free radical-induced damage. As well as evaluating levels of 8-OhdG in peripheral lymphocytes, these authors sought to measure plasma concentrations of several nonenzymatic antioxidants and to assess links between any observed changes in lymphocyte DNA 8-OHdG content and plasma antioxidant levels in these patients versus healthy controls.
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