05/24/2002 By David Loshak
Only a minority of insomniacs who self-administer hypnotics during the day are physiologically aroused.
Indeed, the drug reduces their arousal. This suggests that their self-administration during the day, as at night, is more consistent with therapy-seeking than drug-seeking behaviour, at least in the short term, say researchers at the Sleep Disorders and Research Center, Henry Ford Hospital, Detroit, Michigan, United States.
The researchers noted that previous studies had shown that insomniacs self-administer hypnotics at high nightly rates. The researchers recruited 44 healthy men and women aged 21-55 years to see if this also applied to the daytime.
The volunteers, divided equally between those with and without insomnia, were randomised to receive either triazolam 0.125 mg or 0.25 mg.
Their preference for placebo versus triazolam was assessed at 2300 hours and 0900 hours over seven consecutive days in each phase. In both the night and the day phases, the volunteers received triazolam or placebo in colour-coded capsules on two sampling days or nights and were then required on five subsequent days or nights to choose their preferred capsule.
The order of day and night study phases and the placebo and triazolam sampling days was counterbalanced. In the night phase, the volunteers went to bed from 2330 to 0730 hours and in the day phase they were tested for level of sleepiness-alertness at 1000, 1200, 1400 and 1600 hours by the multiple sleep latency test as well.
They were also tested by mood and performance at 1100 and 1500 hours. The researchers found that more triazolam was chosen at night than during the day. It was also found that there were no dose differences in preferences at night compared with the day or between
insomniacs and non-insomniacs.
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