NEW YORK (Reuters Health) Mar 14 – Results of a genetic analysis of families with members with anorexia nervosa find genetic linkage for susceptibility to the condition on chromosome 1. A report on the finding appears in the March issue of the American Journal of Human Genetics.
"The scientific literature has long supported the role of genetics in the etiology of anorexia nervosa," lead author, Dr. Dorothy E. Grice from the University of Pennsylvania School of Medicine, Philadelphia, said in a statement. "This is the first genetic linkage study to detect specific susceptibility loci for anorexia nervosa and we are excited about the possibility of identifying the particular gene(s) that underlie this linkage signal," she added.
Dr. Grice and colleagues performed a genome-wide linkage analysis of 192 families who had at least two relatives with anorexia nervosa or other eating disorders such as bulimia nervosa.
This analysis found only a modest genetic link. The highest nonparametric linkage (NPL) score the research team found was 1.80 at marker D4S2367 on chromosome 4, they report.
To increase the power to detect a genetic linkage, the investigators analyzed 37 of the families who had at least two affected relatives with a diagnosis of restricting anorexia nervosa, characterized by restricted food intake without binge eating or purging.
This analysis found the highest multipoint NPL score of 3.03 at marker D1S3721 on chromosome 1, Dr. Grice's team reports. "The genotype of additional markers in this region led to a peak multipoint NPL score of 3.45, thereby providing suggestive evidence for the presence of an anorexia nervosa-susceptibility locus on chromosome 1p," Dr. Grice's group comments.
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