מתוך medicontext.co.il
NEW YORK (Reuters Health) – Children with three or more minor physical anomalies are more likely to develop a schizophrenia spectrum disorder than to develop no mental illness or other psychopathology, according to a report published in the February issue of the American Journal of Psychiatry.
Principal investigator Dr. Sarnoff Mednick, and colleagues at Institute of Preventive Medicine in Copenhagen and the University of Southern California in Los Angeles, assessed the psychiatric health of 242 subjects who were evaluated for minor physical anomalies as children nearly 20 years prior. Eighteen specific anomalies were included in the analysis, such as wide-set eyes, low-seated ears, and webbed toes.
Children with three or more anomalies more often developed a schizophrenia spectrum disorder than they developed no mental illness or other psychopathology, the researchers note. The association was also noted in a subset of subjects whose mother or father had been diagnosed with schizophrenia, suggesting an interaction with genetic risk factors.
The researchers postulate that the neurodevelopmental disruptions that produce minor anomalies may also place an individual at risk for schizophrenia spectrum disorders. In addition, the findings suggest that the anomaly status interacts with genetic risk factors to increase the likelihood of schizophrenia spectrum disorder development.
"The mechanisms behind the relation between genetic vulnerability and early stressors such as minor physical anomalies leading to development of schizophrenia spectrum disorder warrants further investigation," Dr. Mednick's team notes.
e-Med Tools
קצר קולע וממוקד
e-Med סמינרים
אי-מד תחקירים
Medscape Tools
Journal Club
מרכזי מידע ושירות
Facebook
מידע למפרסם
מאגר תרופות
מאגר אנשי המקצוע
אינדקס שימושי
חדשות משה"ב
eMed HealthClub
מחקרים קליניים
השאירו תגובה
רוצה להצטרף לדיון?תרגישו חופשי לתרום!