Three and four dose schedules using a pentavalent combination vaccine against diphtheria, tetanus, pertussis, polio and Haemophilus influenzae maintain “satisfactory” antibody levels several years after dosing.
Researchers from Sahlgrenska University and other Swedish centres, with a researcher from Aventis Pasteur MSD, Copenhagen, Denmark, studied a cohort of children who received a pentavalent combination vaccine containing diphtheria toxoid, tetanus toxoid, acellular pertussis, inactivated polio and Haemophilus influenzae type b conjugate as infants. Children received either two or three priming doses.
All children also received a booster dose after around a year. In the initial study, the proportion of children who attained protective antibody concentrations did not differ depending on the schedule. This paper reports follow-up after 4.5 years of 92 and 88 children that received a total of three and four doses respectively.
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