Improved delivery of corticosteroids to the airways in asthmatic children allows maintenance of asthma control at a lower dose.
Extra-fine hydrofluoroalkane 134a-beclomethasone dipropionate (HFA-BDP) can be administered by a breath-activated device to provide long-term maintenance at approximately half the dose of traditional chlorofluorocarbon (CFC)-BDP.
CFC-BDP is traditionally administered using a press-and-breathe metered dose inhaler and spacer (CFC-BDP+S). HFA-BDP is a new CFC-free formulation of BDP.
BDP has been used effectively in both adult and paediatric asthma for a number of years. The breath-activated device can help children who have difficulty coordinating the press-and-breathe metered dose inhalers, the say.
Investigators from Denmark, the United Kingdom, Germany, France, the Netherlands and the United States explain use of high doses of inhaled corticosteroids by asthmatic children can affect biochemical markers of bone formation and resorption and short-term lower leg growth. This makes it important to assess long-term safety in new treatments while maintaining efficacy.
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