SAN FRANCISCO, CA — May 21, 2002 —
Childhood obesity may set the stage for liver damage, with elevated liver enzymes a warning sign, according to researchers. Dr. Yoram Elitsur, of Marshall University School of Medicine, Huntington, West Virginia, United States, presented the findings here Monday at the 103rd annual meeting of the American Gastroenterological Association and Digestive Disease Week (DDW).
Dr. Elitsur and colleagues reviewed the charts of 2,550 patients older than two years, 902 of which included liver enzyme measures.
Their analysis revealed that liver enzymes were elevated in a greater proportion of children who were obese, as defined by the U.S. Centers for Disease Control and Prevention (CDC) nomogram, than in those of normal body mass index. Excluding other clinical reasons that could result in elevated liver enzymes, more than half of the abnormal readings were clearly associated with obesity in the children sampled, he said. Possible other reasons for high readings that were excluded from the sample included drug toxicity, ulcerative colitis,
cholelithiasis, choledochal cyst, biliary atresia, and hepatitis.
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