Laurie Barclay, MD
NEW YORK (MedscapeWire) Apr 19 More conclusive evidence linking pediatric autoimmune neuropsychiatric disorder with group B streptococcus (PANDAS) appears in the April issue of the Archives of Pediatric and Adolescent Medicine.
"To our knowledge, this is the first prospective study to confirm that PANDAS is associated with acute group A beta-hemolytic streptococcal (GABHS) tonsillopharyngitis and responds to appropriate antibiotic therapy at the sentinel episode," write Marie Lynd Murphy, MD, and Michael E. Pichichero, MD, from the University of Rochester Medical Center in New York.
Over a 3-year period, 12 school-aged children with new-onset PANDAS each had the abrupt appearance of severe obsessive-compulsive disorder (OCD) behaviors, accompanied by mild symptoms and signs of acute GABHS tonsillopharyngitis. Although symptoms of OCD included hand washing and preoccupation with germs, the most prominent symptom, seen in 58% of patients, was daytime urinary urgency and frequency without dysuria, fever, incontinence, nocturnal symptoms, or positive urinalysis or urine cultures.
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