Repeated short courses of oral glucocorticoids for treatment of paediatric asthma are not associated with any lasting disturbance in bone metabolism, bone mineralisation or adrenal function, Canadian researchers report.
New courses of oral glucocorticoids were associated with transient decreases in plasma osteocalcin during the five days of administration, but the investigators from Montreal Children’s Hospital and McGill University in Quebec found no significant changes in the children’s urine pyridinoline during the subsequent month.
“There was no cumulative effect on bone density among children with repeated bursts during the preceding 12 months as compared with unexposed children,” they point out. Repeated bursts ranged from 3 to 11 courses of glucocorticoids over the year.
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