Effect Of Feeding Versus Fasting On Bone Turnover Markers

All bone formation and resorption markers are significantly lower in the fed state with the exception of bone alkaline phosphatase.

Decreases in markers from fasting to fed states range from 3.8 ± 0.9 percent for procollagen type I N-terminal propeptide to 17.8 ± 2.6 percent for serum C-telopeptide, report investigators from the Bone Metabolism Group at the University of Sheffield in Sheffield, United Kingdom, and Roche Diagnostics in Penzberg, Germany.

The investigators studied 20 healthy premenopausal women on 10 consecutive days in which they received either breakfast at 08:00 h or no breakfast on alternate days. Two-hour urine collections were obtained each day. Blood samples were taken at 09:00 h daily.

Urine and serum levels of the N-telopeptide cross-link of type I collagen and C-telopeptide as well as urine levels of immunoreactive free deoxypyridinoline were measured as bone resorption markers.

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