Recombinant human erythropoietin (rhEPO) leads to dramatic recovery when administered immediately after acute spinal cord injury (SCI) in rats, investigators report in the current early edition of the Proceedings of the National Academy of Sciences.
Dr. Michael Brines and associates evaluated two rodent models of SCI. In the first model they applied an aneurysm clip at level T3 for 1 minute to produce a moderate compression injury with transient vascular occlusion and pressure-related block of axonal conduction. Disruption of myelin was minimal. When the investigators treated 14 animals with i.p. rhEPO 1000 units/kg immediately after the injury was induced, the rats were able to move all three joints of their hindlimbs 12 hours later.
In contrast, 14 control rats injected with saline after a similar procedure exhibited a flaccid paraplegia for 3 days. By day 28, rhEPO-treated animals achieved a mean motor score of 18 out of a possible 21, compared with a mean of 10 in the control animals (p < 0.001).
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