Ibopamine alone has a more potent mydriatic effect and increase in intraocular pressure in patients with glaucoma than do either phenylephrine or tropicamide. Researchers from the University of Verona, Italy, enrolled 15 patients with primary open-angle glaucoma and 15 healthy subjects, aged between 40 and 70 years (mean 54.8), into this open prospective study.
Assessments were mad of visual acuity, refraction, intraocular pressure (IOP), pupil diameter and anterior segment geometry after instillation of 2% ibopamine. Between 20 and 30 days later, five controls and five glaucoma patients underwent the same assessments using first 10% phenylephrine followed by 1% tropicamide.
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