International Journal of Radiation Oncology, Biology and Physics (IJROBP Online) 05/16/2002 By Elda Hauschildt
Radiation doses that seem safe in breast cancer patients, even at five years, can lead to complications later in life.
Use of large daily fractions, combined with hotspots from overlapping fields, have caused complications such as fibrosis, edema, brachial plexus neuropathy and paralysis, Swedish researchers report.
The investigators from Umea Hospital and the Translational Research Group in Umea retrospectively analysed the clinical records of 150 breast cancer patients followed for 34 years.
They had been treated with radiotherapy following mastectomy to the parasternal, axillary and supraclavicular lymph node regions in the mid- to late-1960s. None had had chemotherapy.
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