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כולסטרול גבוה בילדות מעיד על סיכון להשמנת יתר בגיל מבוגר



Although conventional wisdom is that obesity causes high cholesterol, results of a study in the September issue of the American Journal of Clinical Nutrition suggest that, at least for girls, high cholesterol can be a marker of obesity developing later in childhood.

 “It is not clear how hypercholesterolemia is linked to high adiposity,” write Andrew M. Tershakovec, from the Children’s Hospital of Philadelphia, Pennsylvania, and colleagues. “It seems more likely that hypercholesterolemia acts as a marker of altered metabolism, which results in excessive adiposity.”

 This spinoff from the Bogalusa Heart study compared 58 hypercholesterolemic children (low-density lipoprotein [LDL] levels greater than 75th percentile) with 215 children who had normal cholesterol levels (LDL less than 60th percentile).

 Subjects were age 5 to 6 years at study enrollment, and none were obese. There were equal numbers of girls and boys, and 41% of the children were black. Although the nonhypercholesterolemic children were taller than the hypercholesterolemic children, there were no other significant differences between the two groups.

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