Patients with advanced cancer do not appear to tolerate or to accept a low phenylalanine and low tyrosine diet.
Though the diets have shown some tumour limiting potential in animal models, they were not well tolerated in human subjects, say researchers at Christie Hospital and South Manchester University Hospital, Manchester, England.
Twenty-two patients with advanced metastatic melanoma and 15 patients with metastatic breast cancer were asked to follow a diet of phenylalanine and tyrosine at a dose of 10 mg/kg-1 per day for one month. After one month, the researchers attempted to establish the effect of the diet on nutritional status (body weight, fat free mass, percentage body fat, serum albumin), immune cell function (white cell count, lymphocytes and neutrophils), plasma levels of phenylalanine-tyrosine and tryptophan, and quality of life as measured by Hospital Anxiety and Depression scores.
Three patients with metastatic melanoma and three with metastatic breast cancer agreed to start the diet. All these patients experienced side effects and increases in anxiety and depression.
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