04/15/2002
By David Loshak
Excessive fat in the blood after meals transiently impairs endothelial reactivity via an oxidative burden. This postprandial lipaemia is partly due to a rise in triglyceride levels.
These findings emerge from a study by researchers at the University of Perugia, Italy, and the University of Vienna, Austria into the vascular effects of the postprandial state in postmenopausal women. The researchers sought to clarify these effects after noting that postmenopausal women are at higher risk of coronary heart disease, to which postprandial lipaemia is strictly related.
The researchers tested oral fat loads in 10 postmenopausal women aged 57± 8 years who did not have vascular risk factors or a history of cardiovascular disease. The tests evaluated endothelial function expressed as brachial flow-mediated vasodilation, lipid parameters and reduced glutathione at baseline and at two, four and six hours after the fat loads.
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