The degree of maximum left ventricular wall thickness should be considered as part of a multifactorial approach, rather than as an isolated risk factor, when stratifying risk of sudden death in patients with hypertrophic cardiomyopathy. Sudden death risk from extreme left ventricular wall thickness alone might suggest risk of only in those diagnosed when they are very young age, report researchers in Florence, Italy. These aspects have important implications for risk stratification and treatment, they say.
The researchers analysed the mortality and risk profile of 237 male and female patients aged 24 to 58 (median 41) years classified into five groups, depending on echocardiographic maximum left ventricular thickness. During follow-up of 5 to 19 (median 12) years, 36 patients died of cardiovascular causes, including 16 sudden deaths. Maximum left ventricular thickness was not associated with a risk of sudden death or with overall cardiovascular mortality.
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