NEW YORK (Reuters Health) Jun 06 –
HIV isolates from seven women in Kenya obtained soon after seroconversion all required the CCR5 coreceptor, and none used the CXCR4 coreceptor, regardless of how many viral genotypes were isolated, investigators report.
Dr. E. Michelle Long, of the University of Washington in Seattle, and associates obtained peripheral blood mononuclear cells from five women in Mombasa within 4 weeks of documented seroconversion.
The investigators amplified DNA fragments encompassing the entire envelope-coding region of proviral particles. According to an article in AIDS Research and Human Retroviruses for May 20, genetically homogeneous virus populations were observed in samples from two subjects.
The other three women each exhibited three genetic clusters representing distinct viral species. All viruses were clade A. The coreceptor requirements were determined using two GHOST cell lines expressing CCR5 or CXCR4. “Each viral envelope used CCR5 as a coreceptor and none used CXCR4 for entry,” the investigators write.
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