06/07/2002
By Veronica Rose
A history of fractures in premenopausal women is a warning signal to practitioners, say American clinicians.
The risk for subsequent fractures is increased, regardless of other factors including bone mineral density for osteoporotic fractures.
Researchers from departments within the University of California in San Francisco questioned the possibility that women with a past history of fractures may be at increased risk after the menopause.
Information relative to any lifetime fractures was obtained from 9,086 white women aged 65 years and older, who were ambulatory and participating in the Study of Osteoporotic fractures.
Fracture sites included hip, arm, spine, wrist, leg, ankle, foot and finger. In addition, researchers measured bone mineral density, recorded history of falls, maternal fracture history, drug use, diet, functional status together with any characteristics which are usually associated with osteoporotic fractures.
Proportional hazard models were used to estimate the effects of premenopausal fractures on those occurring after the menopause, particularly during the 12 years study of follow-up.
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