NEW YORK (Reuters Health) Jan 15 – Results of a new study find that women with polycystic ovary syndrome have significantly higher than normal levels of total and LDL cholesterol. However, obese women with polycystic ovary syndrome also have significantly higher levels of HDL cholesterol, which may be somewhat protective.
Dr. Andrea Dunaif, from Northwestern University Medical School, Chicago, and colleagues collected data on 195 white women, 18 to 45 years of age, with polycystic ovary syndrome. The researchers assessed lipid levels in these women and in 62 matched controls.
Among 153 obese women with polycystic ovary syndrome, both total and LDL cholesterol levels were significantly increased compared with obese controls (p < 0.001 for total cholesterol, p = 0.006 for LDL cholesterol). Total and LDL cholesterol levels were also significantly increased in non-obese women with polycystic ovary syndrome compared with controls (p < 0.001 for total and LDL cholesterol), the researchers found.
Compared with obese controls, obese women with polycystic ovary syndrome had significantly elevated HDL cholesterol and triglyceride levels (p = 0.002 for HDL cholesterol, p = 0.04 for triglycerides). After adjusting for alcohol intake, smoking, and exercise the only the differences in LDL and HDL cholesterol remained significant, Dr. Dunaif's group notes.
"Although age, body mass index, and polycystic ovary syndrome status were significant predictors of lipid levels, these factors accounted for no more than 25% of the variance," according to the report in the December 1, 2001, issue of the American Journal of Medicine.
Dr. Dunaif and colleagues conclude that "prospective, long-term studies are needed to evaluate the relation between dyslipidemia and cardiovascular events in women with polycystic ovary syndrome."
"While there is little doubt that polycystic ovary syndrome, independent of obesity, constitutes a significant risk factor for type 2 diabetes, there is, at present, no direct evidence of increased morbidity or mortality from coronary heart disease," Dr. Stephen Franks, from Hammersmith Hospital, London, comments in a journal editorial.
"It would nevertheless be unwise to be complacent about the long-term management of patients with polycystic ovary syndrome. It is quite conceivable that the incidence of coronary heart disease will diverge from normal with age," Dr. Franks notes.
Am J Med 2001;111:607-613, 665-666.
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