NEW YORK (Reuters Health) –
Enrolling in a clinical trial aimed at preventing HIV infection in high-risk women and taking part in risk-reduction counseling results in a decrease in study endpoints, a multinational research team reports.
Therefore, those designing intervention trials must keep this point in mind to ensure that the statistical power of the trial is adequate to test the effect of the intervention.
Dr. Rupert Kaul and colleagues at the University of Nairobi in Kenya, and elsewhere, conducted an interim analysis of an ongoing randomized trial of HIV-STD prophylaxis.
All those who enrolled were provided with prevention services that included risk-reduction counseling, free condoms and prompt treatment of any symptomatic STD.
The researchers evaluated the impact of the trial on the HIV risk-taking behavior in 305 female sex workers in Nairobi by evaluating sexual practices at baseline and at 3-month intervals.
The findings appear in the May 1st issue of the Journal of Acquired Immune Deficiency Syndromes.
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