05/30/2002 By James Adams
Hepatitis B virus (HBV) carriers were found to have lower titers of anti-Plasmodium falciparum ring-infected erythrocyte surface antigen (RESA) compared with individuals with resolved HBV infections in the Brazilian Amazon.
Falciparum malaria and HBV infections are common in this area. Investigators from the Universidade Federal de Mato Grosso in Cuiabá and the Instituto Oswaldo Cruz-Fiocruz in Rio de Janeiro, Brazil, studied residents of gold mine camps in the county of Apiacás, north of Mato Grosso.
Gold miners have a high prevalence of both malaria and HBV infections and are considered to facilitate the spread of both diseases, according to the investigators.
The anti-RESA antibody appears after intense and frequent exposure to Plasmodium falciparum.
High titers may be associated with acquired protection against malaria, but studies have shown conflicting results. In this study, 520 inhabitants from 16 different gold mine camps were interviewed and blood samples were taken between March and June of 1996. One hundred and six blood smears were positive for malaria (Plasmodium falciparum in 56, Plasmodium vivax in 47 and Plasmodium malarie in three). Five hundred seventeen (99.4 per
cent) of the gold miners had previous symptomatic malarial episodes.
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