05/24/2002 By Anne MacLennan
Chronic liver disease is more aggressive in patients infected with both hepatitis B and hepatitis C than in those with only one of these viruses.
More severe liver disease also tends to occur in patients in whom the hepatitis B virus (HBV) is the more active of the two infections, suggests a study from New Delhi, India. Clinical and biochemical profiles of chronic liver disease due to infection with both HBV and hepatitis C virus (HCV) are sketchy, and reports vary on the severity of the disease in these patients. R C Guptan and colleagues from the Departments of Gastroenterology and Pathology, GB Pant Hospital analysed the course of liver disease in patients infected with both viruses versus those with either one of the two.
Among 186 histologically proven non-alcohol chronic liver patients, 30 (16.1 percent) were serologically diagnosed with HBV and HCV dual infection. Researchers compared the clinical profile of this group with that of 30 consecutive patients with HBV-related and 30 with HCV-related chronic liver disease.
Those with both infections were also further grouped according to the predominance of
activity of HBV versus HCV.
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