SAN FRANCISCO, CA — May 20, 2002 —
A new test can help detect delayed type IV allergic reactions to food that can lead to difficult to diagnose dyspepsia, suggest results presented Sunday today at the 103rd annual meeting of the American Gastroenterological Association and Digestive Disease Week (DDW).
The test, a lymphocyte proliferation test (LPT), includes interferon-alpha and uses autologous, human pooled sera to increase the sensitivity and specificity of the available LPT assays.
These changes make the LPT test “knife sharp”, said study investigator Dr. Peter Janetscheck of the Day Clinic, in Munich North, Germany. The study included 210 patients with suspected allergic symptoms, such as urticaria, gastrointestinal symptoms or rash, but with negative immunoglobulin E (IgE) results, and 86 healthy volunteers. Of patients with allergic symptoms, 40 percent had a positive result on a lymphocyte proliferation test (LPT) that includes interferon-alpha and uses autologous, human pooled sera to increase the sensitivity and specificity of the available LPT. Of the 86 healthy volunteers, 2.5 percent showed a positive LPT test reaction.
The modified version of the conventional LPT, with a panel of 44 food allergens, finds that the most common antigens in people with delayed food allergy are soy, milk, and egg proteins.
These are the antigens most commonly suggested in published studies of delayed food allergies, Dr. Janetschek said.
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