The glycosylation gap – the discordance between levels of the glycosylated serum proteins HbA(1c) and fructosamine – predicts nephropathy stage and might be useful for investigating diabetic complications.
Researchers at the University of Cincinnati Medical Center and other centres in Ohio, United States, measured levels of HbA(1c) and fructosamine in samples taken from 153 volunteers. The authors defined the glycosylation gap as the difference between measured HbA(1c) and the level of HbA(1c) predicted from the population regression of HbA(1c) on fructosamine.
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