Wound status after four weeks of treatment can provide valid surrogate markers for healing of venous leg ulcers at 12 or 24 weeks of care.
The markers are log healing rate, log wound area ratio and percentage change in wound area, say researchers at the Department of Dermatology and the Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, United States.
The surrogate markers are considered valuable because they can predict the meaningful clinical endpoint of treatment well before the true outcome can become evident. This is useful with venous leg ulcers, the researchers say, because evaluation of therapies is challenged by the long observation period needed to reach the endpoint of healing.
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