Acute reduction of circulating fatty acids with Acipimox improves insulin secretion in type 2 diabetic patients with low haemoglobin A1c levels.
Investigators from Norwegian University of Science and Technology, in Trondheim, Norway, studied 21 patients with type 2 diabetes and hypertriglyceridaemia alongside 10 age-matched non-diabetic controls. Subjects underwent two hyperglycaemic clamps for 120 minutes each with an infusion of Intralipid and heparin from minute 60 to 120.
In one of the tests, subjects received 250 mg of Acipimox 60 minutes before the hyperglycaemic clamp. A third test including 17 of the diabetic patients was also conducted. In this test, patients followed a three-day low-fat diet before undergoing hyperglycaemic clamps with Acipimox.
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