It is common practice for primary care physicians to empirically prescribe proton pump inhibitors for the treatment of dyspepsia. However, results of a double-blind randomized trial published in the December issue of the American Journal of Gastroenterology showed that in patients with uninvestigated dyspepsia, both placebo and omeprazole reduced the need for endoscopy. Investigators call for a reappraisal of competing strategies.
“In patients with uninvestigated dyspepsia, a common initial management strategy in primary care is to prescribe a course of empiric antisecretory therapy and to refer those patients who do not respond for endoscopy,” write Linda Rabeneck, MD, and colleagues from the Baylor College of Medicine in Houston, Texas.
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