Clozapine (Clozaril) has become the first ever drug to be approved in the US for reducing the risk of suicidal behaviour.
The approval was based on data from the International Suicide Prevention Trial, which compared the use of Clozaril and olanzapine (Zyprexa) in reducing suicidal behaviour amongst patients with schizophrenia or schizo-affective disorder.
Results showed Clozaril reduced the risk of suicide attempts and hospitalisations to prevent suicide by about 25% compared to Zyprexa
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