Many cases of pelvic pain may be related to interstitial cystitis (IC), according to the results of a study using the intravesical potassium sensitivity test (PST). This study, which was reported in the November issue of the American Journal of Obstetrics and Gynecology, suggests that the frequency of IC in the United States may be 20 times greater than previously suspected.
“IC is a clinical syndrome of urinary urgency/frequency and/or pelvic pain. Its presence traditionally has been difficult to detect, both because of the intermittent and progressive nature of the symptoms and because the disease is easily mistaken for other urologic and gynecologic disorders,” write C. Lowell Parsons, MD, from the University of California San Diego Medical Center, and colleagues.
“The intravesical potassium sensitivity helps to identify the presence of IC by detecting the abnormal bladder epithelial permeability that is present in most individuals with IC.” Gynecologists at four U.S. medical centers administered the PST to 244 consecutive unselected patients with pelvic pain and to 47 control subjects. Although 84% of patients reported urologic symptoms, initial clinical diagnosis on the basis of the chief symptomatic complaint(s) was IC in only 1.6% of the patients. Other clinical diagnoses included endometriosis, vulvodynia (vulvar vestibulitis), and pelvic pain.
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