B-vitamin supplementation may reduce some of the elevations in markers of cardiovascular risk seen in patients taking antiepileptic drugs.
Levels of plasma total homocysteine can become elevated in patients taking antiepileptic drugs. Terje Apeland from the department of internal medicine, Rogaland Central Hospital, Stavanger, Norway, and colleagues in Norway and Northern Ireland tested whether supplementation with B-vitamins would affect plasma total homocysteine levels as well as markers of endothelial activation and lipid peroxidation in patients taking antiepileptic agents. Participants were 33 adults taking antiepileptic drugs.
Of these, 23 had fasting elevated homocysteine levels, and 10 had elevated homocysteine levels associated with methionine loading. All the patients received 0.4 mg of folic acid, 120 mg of pyridoxine and 75 mg of riboflavin in a daily dose for 30 days.
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