Jennifer Warner, Medical Writer Oct. 7, 2002
The discovery of a protein that triggers Sjögren syndrome in mice is now providing valuable clues into this autoimmune disorder. Researchers say they’ve already tested a vaccine that, at least in mice, stops the body’s attack on its moisture-producing glands. There are currently no effective treatments for the disease.
In a study published in the Oct. 5 issue of The Lancet, researchers say they’ve identified a protein, known as ICA69, that plays a vital role in the development of Sjögren syndrome. By removing the gene that produces this protein in mice, researchers were able to prevent the disease from developing in the tear glands and substantially limit the disease in the salivary glands.
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