In a multicenter randomized trial reported in the Sept. 26 issue of the New England Journal of Medicine, warfarin or warfarin plus aspirin was better than aspirin alone in preventing composite vascular events after myocardial infarction (MI).
“As compared with aspirin alone, therapy with moderate intensity warfarin combined with aspirin and high-intensity warfarin alone resulted in a reduced risk of reinfarction and ischemic stroke but a higher risk of bleeding,” write Mette Hurlen, MD, from Ulleval University Hospital in Oslo, Norway, and colleagues.
Over four years, 3,630 patients received warfarin targeted at an international normalized ratio of 2.8 to 4.2, aspirin 160 mg daily, or aspirin 75 mg daily plus warfarin targeted at an international normalized ratio of 2.0 to 2.5.
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