Screening for gestational diabetes at 16 weeks rather than 28 weeks is feasible and offers the advantage of preventing complications by earlier intervention, according to results of a study published in the August issue of the Journal of Reproductive Medicine.
The negative predictive value of 16-week screening glucose levels/=135 mg/dL was 55%. “Screening at 16 weeks is a better predictor of gestational diabetes,” Gerard Nahum, MD,
from Duke University Medical Center in Durham, North Carolina, says in a news release.
“It’s more sensitive than screening later, and allows us to focus earlier on women who are at greatest risk. It’s also a more practical screening technique because blood samples drawn during early pregnancy for other tests can also be used for this purpose.”
In this study, 255 pregnant women seen at a private obstetrics practice in Honolulu, Hawaii received a 50-g, one-hour glucose screening test between 14 and 18 weeks of pregnancy. Fourteen women (5%) who had blood plasma glucose levels higher than 135 mg/dL on initial screening had 100-g, three-hour glucose tolerance tests to confirm the diagnosis of gestational diabetes. The remaining 241 women (95%) were screened again between 24 and 32 weeks, and those with levels over 135 mg/dL also received glucose tolerance tests.
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